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Usage of erythromycin:
A significant increase in colchicine plasma concentration is anticipated when co-administered with erythromycin acne erythromycin ophthalmic ointment erythromycin ophthalmic ointment erythromycin moderate CYP3A4 inhibitors such as erythromycin .
If co-administration of colchicine and erythromycin is necessary, the starting dose erythromycin of colchicine may need to be reduced, and the maximum colchicine dose should be lowered .
Patients should be monitored for erythromycin clinical symptoms of colchicine toxicity (see WARNINGS) .
Drug/Laboratory Test erythromycin Interactions Erythromycin interferes with the fluorometric determination of urinary catecholamines .
Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term oral dietary studies conducted with erythromycin stearate in rats up to 400 mg/kg/day and in mice up to about 500 mg/kg/day (approximately 1 to 2 fold of the maximum human dose on a body surface area basis) erythromycin estolate erythromycin dosage erythromycin stearate erythromycin eye ointment did not provide evidence of tumorigenicity .
Erythromycin stearate did not show genotoxic erythromycin topical solution erythromycin eye ointment buy erythromycin erythromycin drug potential in the Ames, and mouse lympho ma assays or induce chromosomal aberrations in CHO cells .
There was no erythromycin apparent effect on male or female fertility in rats treated with erythromycin base by oral gavage at 700 mg/kg/day (approximately 3 times the maximum human dose on a body surface area basis) .
Teratogenic Effects Pregnancy Category B There is no evidence of teratogenicity or any other adverse effect on reproduction in female rats fed erythromycin base by oral gavage at 350 mg/kg/day (approximately twice the maximum erythromycin recommended human dose on a body surface area) prior to and during mating, during gestation, and through weaning .
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