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As age of pediatric patients increases, the clearance of linezolid gradually decreases, and by adolescence mean clearance values approach those zyvox observed for the adult population .
There is wider inter-subject variability in linezolid clearance and systemic drug zyvox exposure (AUC) across all pediatric age groups as compared with adults .
Similar mean daily AUC values were observed in pediatric patients from birth to 11 years of age dosed zyvox every 8 hours (q8h) relative to adolescents or adults dosed every 12 hours (q12h) .
Therefore, the dosage for pediatric patients zyvox up to 11 years of age should be 10 mg/kg q8h .
Pediatric patients 12 zyvox vre what is zyvox zyvox zyvox iv zyvox 600 mg uses iv zyvox zyvox 600 mg zyvox iv side effects years and older should receive 600 mg q12h (see DOSAGE AND ADMINISTRATION) .
NDA zyvox 21-130/S-016/S-017 NDA 21-131/S-013/S-014 NDA 21-132/S-014/S-015 Table 2 .
Pharmacokinetic Parameters of Linezolid in Pediatrics and Adults Following a Single Intravenous Infusion of 10 mg/kg or 600 mg Linezolid (Mean: (%CV); [Min, Max Values]) Neonatal Patients < 1 week (N=10)† ≥ 1 week to ≤ 28 days > 28 days to < 3 Pediatric Patients 3 months zyvox medicine linezolid zyvox zyvox generic buy zyvox online zyvox food interactions zyvox and ssri through 11 Adolescent Subjects and 12 through 17 years‡ AUC = Single dose AUC0-∞ In this data set, “pre-term” is defined as <34 weeks gestational age (Note: Only 1 patient enrolled was pre-term with a postnatal age between 1 week and 28 days) In this data set, “full-term” is defined as ≥34 weeks gestational age Dose of 10 mg/kg Dose of 600 mg or 10 mg/kg up to a maximum of 600 mg Dose normalized to 600 mg Cmax = Maximum plasma concentration; Vss= Volume of distribution; AUC = Area under concentration-time curve; t1/2 = Apparent elimination half-life; CL = Systemic clearance normalized for body weight Gender: Females have a slightly lower volume of distribution of linezolid than males .

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