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Paracetamol in opposition to acetaminophen selective inhibitors of COX-2, despite a similar mechanism of action, reveals weak antiinflammatory activity .
It is likely to result from acetaminophen dose response curve acetaminophen dosage wiki acetaminophen dosage per pound the extracellular accumulation of arachidonic acid and peroxides in the inflammatory tissues, which reduce an inhibitory effect of paracetamol on the prostaglandin production (Fig .
Indeed, paracetamol did not decrease prostanoid concentrations acetaminophen x paracetamol acetaminophen arthritis side effects acetaminophen dosage reddit in the joint fluid of patients suffering from osteoarthrisis (70) .
On the other hand, paracetamol reduced tissue swelling with similar to ibuprofen efficiency after acetaminophen to phenacetin acetaminophen dosage and liver damage acetaminophen safe dosage the oral cavity surgery in humans (71) .
There have been also some studies which demonstrated anti-inflammatory action acetaminophen of paracetamol, e . , nociceptive inhibition acetaminophen and carrageenaninduced rat paw edema (72) .
Therefore, the notion that paracetamol exhibits weak anti-inflammatory properties seems to be more legitimate than the assumption that this drug is devoid of such an As regards safety of paracetamol application in pregnancy, prospective cohort studies in humans have not shown an increase in the prevalence of developmental fetal anomalies in acetaminophen pregnant women who took paracetamol in therapeutic doses, although in some experimental studies on animals paracetamol administered at doses twice as high as the maximum single dose demonstrated embriotoxic action (73) .
Considering the fact that paracetamol is the drug of choice in pregnant women, it acetaminophen should be emphasized that epidemiological studies report the possibility of the association between application of this drug in pregnancy and development of asthma MARTA J”èWIAK-B BENISTA and JERZY Z .

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