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Pharmacokinetics of Bupropion and Metabolites in Patients with Severe Hepatic Cirrhosis: Ratio Relative to Healthy Matched Controls Hydroxybupropion Threo/erythrohydrobupropion Left Ventricular Dysfunction: During a chronic dosing trial with bupropion is wellbutrin used to stop smoking highest dose of wellbutrin how to stop wellbutrin xl wellbutrin in 14 depressed subjects with left ventricular dysfunction (history of CHF or an enlarged heart on x-ray), there was no apparent effect on the pharmacokinetics of bupropion or its metabolites, compared with healthy volunteers .
Age: The effects of age on the pharmacokinetics of bupropion and its metabolites have not been fully characterized, but an exploration of steady-state bupropion concentrations from several depression efficacy trials involving subjects dosed in a range of 300 to 750 mg per day, on a 3times-daily schedule, revealed no relationship between wellbutrin age (18 to 83 years) and plasma concentration of bupropion .
A single-dose pharmacokinetic trial demonstrated that the disposition of bupropion and its metabolites in elderly subjects was similar to that wellbutrin of younger subjects .
These data suggest there is no prominent effect of age on bupropion concentration; however, wellbutrin another single- and multiple-dose pharmacokinetics trial suggested that the elderly are at increased risk for accumulation of bupropion and its metabolites [see Use in Specific Populations (8 .
Gender: Pooled analysis of bupropion pharmacokinetic data from 90 healthy male and 90 healthy female volunteers revealed no sex-related differences in the peak plasma wellbutrin concentrations of bupropion .
The mean systemic exposure (AUC) was approximately wellbutrin 13% higher in male volunteers compared with female volunteers .
The clinical how to stop taking wellbutrin safely what is wellbutrin taken for what is the lowest dose of significance of this finding is unknown .

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