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21 February 2013 Questions and answers Refusal of the marketing authorisation for Qsiva (phentermine / topiramate) Outcome of re-examination On 18 October 2012, the Committee for Medicinal Products for Human Use (CHMP) adopted a negative adipex opinion, recommending the refusal of the marketing authorisation for the medicinal product Qsiva, intended for the treatment of obesity .
The company that applied for authorisation is Vivus adipex BV .
The applicant requested a re-examination of the phentermine hcl coupons phentermine shots phentermine weight loss diary phentermine dosage 37.5 opinion .
After considering the grounds for this request, the CHMP re-examined the initial opinion, and confirmed the refusal of the marketing authorisation on 21 February adipex 2013 .
Qsiva is a medicine that contains the active substances phentermine adipex and topiramate .
It adipex was to be available as modified release capsules .
What was Qsiva expected to be used for? Qsiva was expected to be used to treat severely obese patients (BMI ≥ 35 kg/m2), or patients with obesity (BMI ≥ 30 adipex kg/m2) who have weight-related health problems, such as high blood pressure, type 2 diabetes or abnormal levels of fat in the blood .
How is Qsiva expected to work? The two active substances in Qsiva are adipex appetite suppressants .
Phentermine adipex suppresses appetite by releasing a chemical transmitter called norepinephrine (or noradrenaline) in the hypothalamus, the region of the brain that controls hunger .
Topiramate is thought to act by increasing the body’s energy use, reducing energy efficiency and reducing duromine adverse effects phentermine k29 phentermine hcl uses phentermine not eating not losing the patients’ appetite for food .
The exact mechanisms of action of topiramate are not fully What did the company present to support its application? The effects of Qsiva were first tested in adipex experimental models before being studied in humans .

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