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A significant increase in colchicine plasma concentration is anticipated when co-administered with erythromycin acne erythromycin ophthalmic ointment erythromycin ophthalmic ointment erythromycin moderate CYP3A4 inhibitors such as erythromycin .
If co-administration of colchicine and erythromycin is necessary, the starting dose erythromycin of colchicine may need to be reduced, and the maximum colchicine dose should be lowered .
Patients should be monitored for erythromycin clinical symptoms of colchicine toxicity (see WARNINGS) .
Drug/Laboratory Test erythromycin Interactions Erythromycin interferes with the fluorometric determination of urinary catecholamines .
Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term oral dietary studies conducted with erythromycin stearate in rats up to 400 mg/kg/day and in mice up to about 500 mg/kg/day (approximately 1 to 2 fold of the maximum human dose on a body surface area basis) erythromycin estolate erythromycin dosage erythromycin stearate erythromycin eye ointment did not provide evidence of tumorigenicity .
Erythromycin stearate did not show genotoxic erythromycin topical solution erythromycin eye ointment buy erythromycin erythromycin drug potential in the Ames, and mouse lympho­ ma assays or induce chromosomal aberrations in CHO cells .
There was no erythromycin apparent effect on male or female fertility in rats treated with erythromycin base by oral gavage at 700 mg/kg/day (approximately 3 times the maximum human dose on a body surface area basis) .
Teratogenic Effects Pregnancy Category B There is no evidence of teratogenicity or any other adverse effect on reproduction in female rats fed erythromycin base by oral gavage at 350 mg/kg/day (approximately twice the maximum erythromycin recommended human dose on a body surface area) prior to and during mating, during gestation, and through weaning .

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