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A multi-species effect on the cardiovascular system was observed, including QT interval prolongation in conscious tapentadol dogs .
Effects on female fertility, tapentadol dependence tapentadol pbs nucynta compared to dilaudid nucynta hydrocodone interaction embryofetal development/teratogenicity and postnatal survival were observed in test species, mostly associated with maternotoxicity .
Consistent with other opioids, tapentadol exhibited dependence potential, withdrawal tapentadol uses in telugu tapentadol nasal bioavailability tapentadol nhs palexia and tramadol effects and tolerance development in animals .
Achieved animal/human exposure margins in the nonclinical studies were quite low due to doselimiting toxicity, particularly CNS, thereby limiting the ability of the nonclinical studies to assess the safety of tapentadol despite the nonclinical toxicity profile per se not necessarily representing a greater concern than that of other µ-opioid tapentadol agonists .
There are a number of concerns with the use of tapentadol, which should be considered in a risk-benefit analysis for the proposed indication: As relative exposure in nonclinical studies was generally quite low, the safety assessment of tapentadol will rely tapentadol chile tapentadol dose conversion chart nucynta neuropathy tapentadol y diabetes nucynta primarily on clinical data .
The adequacy of testing for carcinogenic potential was constrained by dose-limiting toxicity in the rodent species tapentadol at exposures below clinical exposure .
Tapentadol should not be used during pregnancy, unless the possible benefits of tapentadol treatment outweigh the risks to the fetus or tapentadol infant .
Tapentadol should not be used nucynta and adderall nucynta generic price nucynta to get high tapentadol er 50 mg tapentadol online during lactation .

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